Maybe. I'm not sure why you'd lose your settings after rebooting, bt try the instructions in
this FAQ.
The basic idea is you calibrate your monitor using whatever it is you want to use, then you capture the results in PowerStrip, which in turn saves them to the registry. Then you can apply those calibrated results at will in all the usual PowerStrip ways (profiles, hotkeys, etc.).
I'm curious about something though: you have two monitors, and two different graphics cads. But both of your two graphics cards support dual monitors. Why are you using the 6600GT?